Gujarati
Hindi
4.Principles of Inheritance and Variation
normal

Assertion : Persons suffering from haemophilia fail to produce blood clotting factor $VIII$.

Reason : Prothrombin producing platelets in such persons are found in very low concentration.

A

If both Assertion and Reason are correct and the Reason is a correct explanation of the Assertion.

B

If both Assertion and Reason are correct but Reason is not a correct explanation of the Assertion.

C

If the Assertion is correct but Reason is incorrect.

D

If both the Assertion and Reason are incorrect.

(AIIMS-2008)

Solution

Haemophilia bleeding disorder is a group of hereditary genetic disorders that impair the body’s ability to control blood clotting or coagulation. In its most common form, Hemophilia $A$, clotting factor $VIII$ is absent. In Haemophilia $B$, factor $IX$ is deficient. Factor $VIII$ participates in blood coagulation; it is a cofactor for factor $IXa$ which, in the presence of $Ca^{+2}$ and phospholipids forms a complex that converts factor $X$ to the activated form $Xa$. Defects in this gene results in hemophilia $A$, a common recessive $X-$ linked coagulation disorder. Prothrombin producing platelets in such persons are not found in very low concentration.

Standard 12
Biology

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