Give differences : Haemophilia and Sickle-cell Anaemia
Haemophilia | Sickle-cell Anaemia |
$(1)$ It occur due to a defective recessive allele present on the $X$-chromosome. | $(1)$ It occurs due to point mutation i.e. a single base pair change leads to a change in amino acid. |
$(2)$ The defective allele produce nonfunctional protein which later form a non-functional protein which later form a non-functional cascade of protein involving in blood clotting | $(2)$ In this glutamic ($Glu$) acid is replaced by Valine ($Val$) at sixth position of beta globin chain of haemoglobin molecule. |
$(3)$ It is a sex-linked recessive disorder. | $(3)$ It is an autosomal linked recessive disorder. |
$(4)$ More males are affected than females. | $(4)$ Both males and females are affected equally. |
:Match the columns :
Column $I$ |
Column $II$ |
$(a)$ Sickle cell anaemia | $(x)$ Homogentisic acid |
$(b)$ Alkaptonuria | $(y)$ Melanin pigmentsare absent |
$(c)$ Albinism | $(z)$ More amount of phenyl alanine |
$(d)$ Phenyl Ketonuria | $(w)$ Defective haemoglobin |
Sex linked disease is
Sickle cell anaemia is due to
Given below is a highly simplified representation of the human sex chromosomes from a karyotype. The gene $'a'$ and $'b'$ could be of
If a character is always transmitted directly from a father to all his sons and from their sons to all their sons, then which chromosome carries the gene for the character