Lesch Nyhan disease is an X- linked recessive disorder that causes neurological damage in human bein

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4.Principles of Inheritance and Variation

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Lesch Nyhan disease is an $X-$linked recessive disorder that causes neurological damage in human beings. $A$ survey of $500$ mates from a caucasion population revealed that $20$ were effected with this disorder. What is the frequency of the normal allele in this population?

A

$9.6$

B

$0.8$

C

$0.096$

D

$96$

Solution

$q^{2} \Rightarrow \frac{20}{500} \Rightarrow \frac{1}{25} \Rightarrow 0.2$

$q=0.2$

$p+q=1$

$p=0.8$

Standard 12

Biology

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