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4.Principles of Inheritance and Variation
medium
Sickle cell anaemia is
A
An autosomal linked dominant trait
B
Caused by substitution of glutamic acid by valic acid in the $\beta$-globin chain of haemoglobin
C
Caused by a change in $3$ base pairs of $DNA$
D
Characterized by elongated sickle like $RBCs$ with a nucleus
Solution
Sickle cell anaemia is caused by a change in a single base pair of DNA. It is an autosomal recessive genetic disease reported from Negroes. In sickle cell haemoglobin the glutamic acid in beta haemoglobin chain is replaced by valine.
Standard 12
Biology
