Sickle­cell anaemia is

  • [AIPMT 2009]
  • A

    caused by substitution of valine by glutamic acid in the beta globin chain of haemoglobin

  • B

    caused by a change in a single base pair of $DNA$

  • C

    characterized by elongated sickle like $RBCs$ with a nucleus

  • D

    an autosomal linked dominant trait.

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