Write a note on lymphoid organs.

These are the organs where origin and /or maturation and proliferation of lymphocytes occur.

The primary lymphoid organs are bone marrow and thymus where immature lymphocytes differentiate into antigen sensitive lymphocytes.

After maturation the lymphocytes migrate to secondary lymphoid organs like spleen, lymph nodes, tonsils, Peyer's patches of small intestine and appendix.

The secondary lymphoid organs provide the sites for interaction of lymphocytes with the antigen, which then proliferate to become effector cells.