In which of the following disorder a single protein that is a part of the cascade of proteins involved in blood clotting is affected?

Lesch Nyhan disease is an $X-$linked recessive disorder that causes neurological damage in human beings. $A$ survey of $500$ mates from a caucasion population revealed that $20$ were effected with this disorder. What is the frequency of the normal allele in this population?

The chromosome shown in the diagram below is broken at the points which are indicated by the arrows and the genes between these points became inverted

The resulting order of the genes will be

The movement of a gene from one linkage group to another is called