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10.Biotechnology and its Application
normal
Which enzyme was targetted during the first clinical gene therapy given in $1990$ to a four year- old girl?
A
Monoamine oxidase
B
Tyrosine oxidase
C
Pyruvate dehydrogenase
D
Adenosine deaminase
Solution
The first clinical gene therapy was given in $1990$ to a four- year- old girl with adenosine deaminase ($ADA$ deficiency). This enzyme is crucial for the immune system to function because in its absence lymphocytes proliferation is inhibited. Without $T$ cells, $ADA-$deficient children are wide open to the attacks of viruses and bacteria.
Standard 12
Biology
