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5.Molecular Basis of Inheritance
medium
Which enzyme will be produced in a cell if there is a nonsense mutation in the lac $Y$ gene?
A
Transacetylase
B
Lactose permease and transacetylase
C
$\beta$-galactosidase
D
Lactose permease
(NEET-2013)
Solution
(c) : A nonsense mutation is the one which stops polypeptide synthesis due to the formation of termination or nonsense codon. In lac operon, sequence of structural genes is $Z, Y$, and $A$, which respectively code for $\beta$-galactosidase, lactose permease and transacetylase. If the gene $Y$ has nonsense mutation, gene expression will stop at it, resulting in nonexpression of both gene $Y$ and successive gene $A$. Thus, only $\beta$-galactosidase enzyme will be produced.
Standard 12
Biology