5.Molecular Basis of Inheritance
medium

Which enzyme will be produced in a cell if there is a nonsense mutation in the lac $Y$ gene?

A

Transacetylase

B

Lactose permease and transacetylase

C

$\beta$-­galactosidase

D

Lactose permease

(NEET-2013)

Solution

(c) : A nonsense mutation is the one which stops polypeptide synthesis due to the formation of termination or non­sense codon. In lac operon, sequence of structural genes is $Z, Y$, and $A$, which respectively code for $\beta$-­galactosidase, lactose permease and transacetylase. If the gene $Y$ has nonsense mutation, gene expression will stop at it, resulting in non­expression of both gene $Y$ and successive gene $A$. Thus, only $\beta$-­galactosidase enzyme will be produced.

Standard 12
Biology

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