4.Principles of Inheritance and Variation
medium

Thalassemia and sickle cell anaemia are caused due to a problem in globin molecule synthesis. Select the correct statement.

A

Both are due to a quantitative defect in globin chain synthesis.

B

Thalassemia is due to less synthesis of globin molecules.

C

Sickle cell anaemia is due to a quantitative problem of globin molecules.

D

Both are due to a qualitative defect in globin chain synthesis.

(NEET-2017)

Solution

(b): Sickle cell anaemia is caused due to point mutation in which at the 6th position of beta globin chain, glutamic acid is replaced by valine. Thus, it is a qualitative defect in functioning of globin molecules.Thalassemia is caused due to either mutation or deletion which ultimately results in reduced rate of synthesis of one of the globin chains that make up haemoglobin. Hence, it is a quantitative defect in functioning of globin molecules.

Standard 12
Biology

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